Metal Nanoparticle coupled Artificial T Cell Stimulator Development Service

Metal Nanoparticle coupled Artificial T Cell stimulator Overview

Metal nanoparticle-conjugated artificial T cell stimulators represent an effective strategy for enhancing T cell activation. This approach holds the potential to revolutionize current T cell therapies by simplifying the manufacturing process and enabling direct in vivo T cell stimulation, thus overcoming the limitations associated with conventional ex vivo cell culture methods. Ultimately, this strategy has great potential to improve the efficacy and accessibility of T cell-based immunotherapies for a wider range of patients.

Fig.1 Tolerogenic artificial T cell stimulator nanoparticles.^1,3

Metal Nanoparticle coupled Artificial T Cell Stimulator Development Service at Creative Biolabs

Creative Biolabs offers a comprehensive metal nanoparticle coupled artificial T cell stimulator development service to overcome the limitations of conventional T cell therapies. We make use of chemical coupling technology to couple T cell activation signals to metal nanoparticles. Our experienced scientists can precisely control the density and orientation of these ligands on the nanoparticle surface, optimizing artificial T cell stimulators’ function for specific therapeutic applications. We provide an extensive selection of customization possibilities, including the choice of metal nanoparticle, ligand selection, and artificial T cell stimulator design. Furthermore, we provide comprehensive characterization services, including particle size analysis, zeta potential measurement, ligand density determination, and in vitro and in vivo efficacy evaluation. By leveraging our expertise and advanced technologies, we can tailor artificial T cell stimulator-metal nanoparticle conjugates to meet the unique requirements of your research or therapeutic development program.

Coupling T Cell Activation Signals

• Signal 1: MHC molecules
• Signal 2: Costimulatory molecules
• Signal 3: Cytokine production inducers

Available Metal Nanoparticles

Several types of metal nanoparticles have shown promise in artificial T cell stimulator development, which include but are not limited to:

• Gold nanoparticles
• Iron nanoparticles
• Platinum nanoparticles

What Will You Gain

• Wide range of nanoparticle options
• Customizable ligand selection and artificial T cell stimulator design to meet specific research needs
• Precise control over ligand density and orientation on the nanoparticle surface
• Rigorous quality control
• Team of experienced scientists with expertise in nanotechnology, immunology, and drug delivery.

Data Display

Summary: This study demonstrates a novel antigen-specific CD4+ T cell expansion platform utilizing metal nanoparticle-based artificial T cell stimulators coated with MHC II and co-stimulatory molecules. These MHC II artificial T cell stimulators effectively expanded antigen-specific CD4+ T cells with potent effector functions, including robust cytokine production and cytolytic activity. Furthermore, the platform facilitated CD4+ T cell-mediated help to CD8+ T cells, enhancing their function and antitumor activity. Importantly, this approach proved successful in expanding both murine and human CD4+ T cells, including rare subsets. These findings highlight the versatility of nanoparticle-based artificial T cell stimulators in enriching, expanding, and modulating CD4+ T cell responses, with significant implications for the development of novel immunotherapies.

Fig.2 Metal nanoparticle-based artificial T cell stimulators coated with MHC II and co-stimulatory molecules stimulate murine CD4⁺ T lymphocytes.^2,3

Fig.3 Metal nanoparticle-based artificial T cell stimulators coated with MHC II and co-stimulatory molecules promote CD4⁺ T cell cytotoxicity.^2,3

Leveraging years of T cell biology research, Creative Biolabs excels in designing and manufacturing high-quality, customized artificial T cell stimulators. Our deep understanding of T cell biology ensures that our artificial T cell stimulators are precisely tailored to your specific research or therapeutic goals. If you want to know more details about our metal nanoparticle coupled artificial T cell stimulator development service, please feel free to contact us.

References

1. Horwitz, David A., Sean Bickerton, and Antonio La Cava. "Strategies to use nanoparticles to generate CD4 and CD8 regulatory T cells for the treatment of SLE and other autoimmune diseases."Frontiers in Immunology 12 (2021): 681062.
2. Isser, Ariel, et al. "Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy." Nature Communications 13.1 (2022): 6086.
3. Distributed under Open Access License CC BY 4.0, without modification.