Sensing System based Next-Generation TIL Development Service

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The Necessary of Next-generation TIL Development Service

Cancer is a leading cause of death worldwide, highlighting the urgent need for effective treatment strategies. The adoptive transfer of tumor-infiltrating lymphocytes (TILs) is a promising method in immunotherapy that has demonstrated clinical safety and effectiveness in many trials. However, the success of TIL infusion in generating an anti-tumor response is restricted to a limited group of cancer patients. Consequently, there is an immediate need for innovative methods to improve the effectiveness of TIL-based therapies.

Fig.1 Next-generation tumor-infiltrating lymphocyte (TIL) therapy. Fig.1 Overview of next-generation TIL therapy.¹

Sensing System based Next-Generation TIL Development Service at Creative Biolabs

Creative Biolabs provides an innovative sensing system based next-generation TIL development service. By harnessing advanced genetic engineering techniques, we are able to meticulously engineer TIL cells with sophisticated sensor systems that allow for the real-time monitoring of these immune cells as they navigate through the complex environment of the body. This cutting-edge approach not only facilitates the identification and selection of TIL cells exhibiting heightened anti-tumor activity but also plays a crucial role in optimizing treatment strategies tailored to individual patient needs. Throughout the process, we strictly comply with regulatory requirements and enable rigorous quality control. Backed up by our experienced scientists, we are committed to delivering satisfactory results in customers' desired times.

Our sensing system based next-generation TIL development service covers the whole development process from the initial to validation. In addition, we also take advantage of our experience and expertise on TIL research to support global customers in preclinical and clinical studies. Listed below is our service package, including:

TIL isolation: We use single-cell sequencing technology, bioinformatics analysis, and other technologies to accurately screen TIL subpopulations that can specifically kill tumor cells
TIL expansion: TILs are co-cultured with tumor cells or immune cells to simulate the in vivo microenvironment and promote the activation and proliferation of TILs.
TIL engineering: We design and engineer sensing systems according to customers' unique requirements. And then we take advantage of advanced genetic engineering technology to integrate the customized sensing system with TIL to enable real-time monitoring and optimization of the entire process and enhance its anti-tumor activity.
Functional characterization and quality control: Our platforms empower to comprehensively evaluate the biological activity of engineered TILs from multiple aspects such as phenotype, cytotoxicity, proliferation ability, cytokine release, cell viability, cell purity, endotoxin, etc., to ensure their efficacy and safety.
Preclinical and clinical development support: We offer comprehensive preclinical and clinical development support for next-generation TIL therapy, encompassing a wide range of services to accelerate your program from early-stage research to clinical trials.

Sensing System Types Available at Creative Biolabs

Sensing systems play a crucial role in optimizing TIL development and therapy. Here we provide several key types of sensing systems that can be integrated into next-generation TIL development:

Fig.2 Sensing system types. (Creative Biolabs Original) Fig.2 Diverse sensing system types.

Key Features of Our Service:

Real-time Monitoring of TIL Behavior
Personalized TIL Therapy
Enhanced Quality Control
One-stop customized service
Rapid timeline

Customer Review

La***i*s

I recently had the opportunity to utilize Creative Biolabs' Sensing System-Based Next-Generation TIL Development Service, and I am thoroughly impressed with the results. Their team demonstrated outstanding capabilities and professionalism throughout the entire process from initial consultation to final delivery, providing very thoughtful pre-sales and after-sales services to help my project move forward. Their cutting-edge technology and innovative approach provided us with highly effective tumor-infiltrating lymphocytes that significantly enhanced our research outcomes. The responsiveness and support from the staff made the experience smooth and efficient, and I appreciate their commitment to quality. I would highly recommend Creative Biolabs to anyone seeking advanced solutions in TIL development!

17/Sep/2024

Frequently Asked Questions

Q1: What process does the service follow?

A1: Our service encompasses the whole process including tumor tissue collection, TIL isolation and expansion, gene editing and modification, quality control and evaluation, and refusion. We carefully monitor and adhere to each stage to ensure that the finished product is dependable and operates effectively.

Q2: What is the difference between TIL and CAR T?

A2: TIL therapy differs from CAR T-cell therapies primarily in the source of the T cells. In CAR T-cell therapies, T cells are harvested from the patient's bloodstream. In contrast, TIL therapy involves isolating T cells directly from the patient's tumor tissue, utilizing these immune cells that have already engaged with the cancer cells in the tumor microenvironment.

If you want to know more about our sensing system based next-generation TIL development service, please feel free to get in touch with us.

Reference

Arnaud, Marion, George Coukos, and Alexandre Harari. "Towards next generation TIL therapy: TILs enriched in neoepitope specific T cells." Clinical and Translational Medicine 13.1 (2023). Distributed under Open Access License CC BY 4.0, without modification.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.