Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
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T cell therapies have shown remarkable clinical efficacy in bone marrow and organ transplantation, cancer immunotherapy, viral infections, and auto-immune diseases. However, T cell are also involved in deleterious side effects. For instance, administration of engineered T cells can damage the normal tissues due to on-target/off-tumor effects. Physiological regulation of T cell activation is achieved by several mechanisms including immune inhibitory receptors such as CTLA4 and PD1, which play pivotal roles in reducing or terminating T cell responses. Inhibitory receptors can be up-regulated during T cell priming to taper immune responses or basally expressed to regulate activation thresholds. A safety CAR (sCAR) contains an extracellular scFv fused to inhibitory domains that prevent the activity of CAR-T cells.
For example, mice deficient of the inhibitory domain CTLA-4 exhibit massive T cell activation and proliferation and eventually succumb to severe systemic autoimmune disease with infiltration of activated T cells. Moreover, loss of PD-1, another inhibitory signaling domain specifically expressed on activated T cells, induces progressive arthritis and accelerates insulitis in nonobese diabetic (NOD) mice. Thus, modulation of the inhibitory signaling domain CTLA-4 or PD-1 during T cell stimulation can selectively divert off-target immunotherapy responses.
Creative Biolabs possesses the most exquisite service platform for CAR-T cell therapy. With efforts from numerous researches and years of experience, we have developed a variety of effective methods to improve the safety for CAR-T cell therapy. Safety CAR can regulate the activity of T cells, and inhibit the secretion of cytokine and off-tumor effect, further improve the safety of CAR-T cell therapy. Creative Biolabs provides the most advanced safety CAR construction service for customers all over the world.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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