CAR-engineered T cell therapy has been rapidly developing in recent years. It has achieved impressive curative effects on many types of cancers. However, there are some adverse events following treatment with CAR-T cell therapy. Marked CAR-T cells express not only CARs but also tumor epitopes that can be recognized by an existing monoclonal antibody. If severe adverse effects take place, administration of the specific monoclonal antibody can clear CAR-T cells with no additional off-tumor effects. These monoclonal antibodies are simultaneously able to treat tumors as well. Creative Biolabs provides design and construction services for Marked CAR.
With consistent dedications in research and testing, Creative Biolabs has developed many novel CAR constructions that allow the clear of CAR-T cells in time and thus limit the side effects. The great advantage of marked CAR is that it can clear CAR-T cells and alleviate adverse symptoms through administration of a monoclonal antibody.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
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