AANAT

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The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP240 AANAT (MTNR1A Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human AANAT-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP241 AANAT (MTNR1B Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human AANAT-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1640 AANAT (MTNR1A Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human AANAT-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1641 AANAT (MTNR1B Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human AANAT-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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