APOB

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP23 APOB (LSR Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human APOB-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP24 APOB (OLR1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human APOB-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP290 APOB (LDLR Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human APOB-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1423 APOB (LSR Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human APOB-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1424 APOB (OLR1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human APOB-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1690 APOB (LDLR Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human APOB-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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