CD44

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11.CD44 is expressed in a large number of mammalian cell types. CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. it is responsible for mediating communication and adhesion between adjacent cells and between cells and the extracellular matrix (ECM). In addition to its role in cellular adhesion, CD44 can direct intracellular signaling for growth and motility, and thus it is involved in many types of cancers, including breast, lung, prostate, ovarian, cervical, and colorectal cancers and neuroblastoma.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC226 T cell Second ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-LC372 T cell ~8kb Lentiviral scFv-PD1-CD28-CD3ζ Mouse Inquiry
CAR-LC373 T cell ~8kb Lentiviral scFv-PDL1-CD28-CD3ζ Mouse Inquiry
CAR-LC374 T cell ~8kb Lentiviral scFv-PDL2-PD1-CD28-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC700 Lentivirus Second scFv-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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