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CD87

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The Urokinase receptor, also known as uPA receptor or uPAR or CD87 (Cluster of Differentiation 87), is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. uPAR plays a central role in cell surface-associated plasminogen activation, entailing proteolytic degradation of the extracellular matrix surrounding the cells. The prognostic significance of uPAR in non-small cell lung cancer is apparent for patients with the histologic subtype of squamous cell carcinoma, where high levels of uPAR is an independent marker of prognosis, as evaluated in tumour extracts. Like in non-small cell lung cancer, uPAR domain I present in high concentrations in preoperative plasma independently predicts poor survival of patients with ovarian cancer.

Associated Disease
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-LC265 Anti-CD87 h(41BB-CD3ζ) CAR, pCDCAR1 Human Mouse scFv-41BB-CD3ζ-IL12 Lentiviral T cell   Add to Cart   Datasheet
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