CLDN6

Claudins are transmembrane proteins and important components of tight junctions (TJs), which are central for the regulation of paracellular permeability and the maintenance of epithelial cell polarity. The downregulation of several claudins in cancer is consistent with the disruption of TJs during tumorigenesis. However, claudin overexpression, has been reported in various cancers. The dysregulated expression of claudins in cancer occurs at both transcriptional and post-transcriptional level. CLDN6 is expressed in tissues of various cancers while expression in normal non-cancer tissues is limited to placenta. Such cancers include ovarian cancer, in particular ovarian adenocarcinoma and ovarian teratocarcinoma.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC191 T cell First ~8kb Lentiviral scFv-CD3ζ Human Inquiry
CAR-LC192 T cell Third ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC257 T cell Second h27.108 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC258 T cell Second h27.204v2 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC670 Lentivirus Second scFv-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC728 h27.108 Lentivirus Second scFv (h27.108)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC729 h27.204v2 Lentivirus Second scFv (h27.204v2)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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