Claudins are transmembrane proteins and important components of tight junctions (TJs), which are central for the regulation of paracellular permeability and the maintenance of epithelial cell polarity. The downregulation of several claudins in cancer is consistent with the disruption of TJs during tumorigenesis. However, claudin overexpression, has been reported in various cancers. The dysregulated expression of claudins in cancer occurs at both transcriptional and post-transcriptional level. CLDN6 is expressed in tissues of various cancers while expression in normal non-cancer tissues is limited to placenta. Such cancers include ovarian cancer, in particular ovarian adenocarcinoma and ovarian teratocarcinoma.

Associated Disease
  • CAR Vector Products
  • CAR Viral Particles
  • Antibody Clone:
  • Receptor Construction:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-LC191 Anti-CLDN6 h(CD3ζ) CAR, pCDCAR1 Human Human scFv-CD3ζ Lentiviral T cell   Inquiry
CAR-LC192 Anti-CLDN6 h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Inquiry
CAR-LC257 Anti-CLDN6 (h27.108) h(41BB-CD3ζ) CAR, pCDCAR1 Human h27.108 Human scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
CAR-LC258 Anti-CLDN6 (h27.204v2) h(41BB-CD3ζ) CAR, pCDCAR1 Human h27.204v2 Human scFv-41BB-CD3ζ Lentiviral T cell   Inquiry

Key Updates

Receive the latest news and insights to your inbox.