CLEC4M

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This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-M0019-YC Anti-CLEC4M (120612) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 120612 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0020-YC Anti-CLEC4M (DC28) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human DC28 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0021-YC Anti-CLEC4M (118A8.05) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 118A8.05 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0022-YC Anti-CLEC4M (120604) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 120604 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0023-YC Anti-CLEC4M (128G8) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 128G8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0024-YC Anti-CLEC4M (16E6) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 16E6 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0025-YC Anti-CLEC4M (2U25) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 2U25 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0430-YC Anti-CLEC4M (120612) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 120612 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0431-YC Anti-CLEC4M (DC28) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human DC28 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0432-YC Anti-CLEC4M (118A8.05) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 118A8.05 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0433-YC Anti-CLEC4M (120604) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 120604 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0434-YC Anti-CLEC4M (128G8) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 128G8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0435-YC Anti-CLEC4M (16E6) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 16E6 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-M0436-YC Anti-CLEC4M (2U25) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 2U25 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7116 Anti-CLEC4M (CBXC-0886) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-0886 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7227 Anti-CLEC4M (CBXC-0467) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXC-0467 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7596 Anti-CLEC4M (CBXC-0886) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBXC-0886 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ7707 Anti-CLEC4M (CBXC-0467) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human CBXC-0467 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY7194 Anti-CLEC4M (CBFYC-1928) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-1928 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY7195 Anti-CLEC4M (CBFYC-1929) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-1929 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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