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Cs-1(CD2 subset-1) also called SLAMF7(Signaling Lymphocytic Activation Molecule Family member 7) or CD319, is a member of the signaling lymphocyte activating-molecule-related receptor family, as a cell surface antibody target selectively expressed in plasma cells.Cs-1 can have activating or inhibitory effects, depending on the absence or presence of an adaptor protein, and Natural Killer Cells express the adaptor protein required for activation via Cs-1.The potential of the Cs-1 pathway to regulate Natural Killer Cell cytotoxicity in multiple myeloma is currently under investigation. Cs-1 is a cell surface glycoprotein that was recently identified as a novel target for multiple myeloma (MM) treatment because of its expression on tumor cells from the majority of MM patients. Currently, the function of CS1 in MM cells is unknown. In NK cells, CS1 acts as a self-ligand and mediates homophilic interaction. Preliminary data suggest that both CS1-CAR T cells and CS1-CAR NK cells are effective in eradicating MM cells in vitro and in vivo.
CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
CAR-NK-1-M329-2 | Anti-CS1 scFv h(CD28) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD28 | Lentiviral | NK cell | ||
CAR-NK-1-M329-G | Anti-CS1 scFv h(FcεRIγ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-FcεRIγ | Lentiviral | NK cell | ||
CAR-NK-1-M329-Z | Anti-CS1 scFv h(CD3ζ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD3ζ | Lentiviral | NK cell | ||
CAR-NK-2-M329-2Z | Anti-CS1 scFv h(CD28-CD3ζ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD28-CD3ζ | Lentiviral | NK cell | ||
CAR-NK-2-M329-4G | Anti-CS1 scFv h(CD4-FcεRIγ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD4-FcεRIγ | Lentiviral | NK cell | ||
CAR-NK-2-M329-4Z | Anti-CS1 scFv h(CD4-CD3ζ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD4-CD3ζ | Lentiviral | NK cell | ||
CAR-NK-2-M329-8Z | Anti-CS1 scFv h(CD8-CD3ζ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD8-CD3ζ | Lentiviral | NK cell | ||
CAR-NK-2-M329-BG | Anti-CS1 scFv h(CD28-FcεRIγ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD28-FcεRIγ | Lentiviral | NK cell | ||
CAR-NK-2-M329-BZ | Anti-CS1 scFv h(41BB-CD3ζ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-41BB-CD3ζ | Lentiviral | NK cell | ||
CAR-NK-2-M329-CZ | Anti-CS1 scFv h(b2c-CD3ζ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-b2c-CD3ζ | Lentiviral | NK cell | ||
CAR-NK-3-M329-2BZ | Anti-CS1 scFv h(CD28-41BB-CD3ζ) CARNK, pCDCAR1 | Human | Luc90 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral | NK cell | ||
CAR-LC302 | Anti-SLAMF7 (Luc63) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | Luc63 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC303 | Anti-SLAMF7 (Luc63) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | Luc63 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC304 | Anti-SLAMF7 (Luc90) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | Luc90 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC305 | Anti-SLAMF7 (Luc90) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | Luc90 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC306 | Anti-SLAMF7 (Luc34) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | Luc34 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC307 | Anti-SLAMF7 (Luc34) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | Luc34 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC308 | Anti-SLAMF7 (LucX1) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | LucX1 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC309 | Anti-SLAMF7 (LucX1) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 | Human | LucX1 | Mouse | FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ | Lentiviral | T cell | ||
CAR-LC365 | Anti-SLAMF7×FN1 h(CD28-41BB-CD3ζ, cMYCmu) Dual CAR, pCDCAR1 | Human | Luc63 | Mouse | scFv (SLAMF7)-CD28-41BB-CD3ζ/scFv (FN)-cMYCmu | Lentiviral | T cell |
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