Cs-1

Cs-1(CD2 subset-1) also called SLAMF7(Signaling Lymphocytic Activation Molecule Family member 7) or CD319, is a member of the signaling lymphocyte activating-molecule-related receptor family, as a cell surface antibody target selectively expressed in plasma cells.Cs-1 can have activating or inhibitory effects, depending on the absence or presence of an adaptor protein, and Natural Killer Cells express the adaptor protein required for activation via Cs-1.The potential of the Cs-1 pathway to regulate Natural Killer Cell cytotoxicity in multiple myeloma is currently under investigation. Cs-1 is a cell surface glycoprotein that was recently identified as a novel target for multiple myeloma (MM) treatment because of its expression on tumor cells from the majority of MM patients. Currently, the function of CS1 in MM cells is unknown. In NK cells, CS1 acts as a self-ligand and mediates homophilic interaction. Preliminary data suggest that both CS1-CAR T cells and CS1-CAR NK cells are effective in eradicating MM cells in vitro and in vivo.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC302 T cell Second Luc63 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC303 T cell Second Luc63 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC304 T cell Second Luc90 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC305 T cell Second Luc90 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC306 T cell Second Luc34 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC307 T cell Second Luc34 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC308 T cell Second LucX1 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC309 T cell Second LucX1 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC310 T cell Second LucX2 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC311 T cell Second LucX2 ~8kb Lentiviral FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Mouse Inquiry
CAR-LC351 T cell Second ~8kb Lentiviral scFv-41BB-CD3ζ/EGFRt Mouse Inquiry
CAR-LC352 T cell Second ~8kb Lentiviral scFv-CD28-CD3ζ/EGFRt Mouse Inquiry
CAR-LC365 T cell Third Luc63 ~8kb Lentiviral scFv (SLAMF7)-CD28-41BB-CD3ζ/scFv (FN)-cMYCmu Mouse Inquiry
CAR-NK-1-M329-2 NK cell First Luc90 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-NK-1-M329-G NK cell First Luc90 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-NK-1-M329-Z NK cell First Luc90 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-NK-2-M329-2Z NK cell Second Luc90 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-NK-2-M329-4G NK cell Second Luc90 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-NK-2-M329-4Z NK cell Second Luc90 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-NK-2-M329-8Z NK cell Second Luc90 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-NK-2-M329-BG NK cell Second Luc90 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-NK-2-M329-BZ NK cell Second Luc90 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-NK-2-M329-CZ NK cell Second Luc90 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-NK-3-M329-2BZ NK cell Third Luc90 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-NK-3-M329-2XZ NK cell Third Luc90 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON