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Cs-1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Cs-1(CD2 subset-1) also called SLAMF7(Signaling Lymphocytic Activation Molecule Family member 7) or CD319, is a member of the signaling lymphocyte activating-molecule-related receptor family, as a cell surface antibody target selectively expressed in plasma cells.Cs-1 can have activating or inhibitory effects, depending on the absence or presence of an adaptor protein, and Natural Killer Cells express the adaptor protein required for activation via Cs-1.The potential of the Cs-1 pathway to regulate Natural Killer Cell cytotoxicity in multiple myeloma is currently under investigation. Cs-1 is a cell surface glycoprotein that was recently identified as a novel target for multiple myeloma (MM) treatment because of its expression on tumor cells from the majority of MM patients. Currently, the function of CS1 in MM cells is unknown. In NK cells, CS1 acts as a self-ligand and mediates homophilic interaction. Preliminary data suggest that both CS1-CAR T cells and CS1-CAR NK cells are effective in eradicating MM cells in vitro and in vivo.

Associated Disease
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-NK-1-M329-2 Anti-CS1 scFv h(CD28) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD28 Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-1-M329-G Anti-CS1 scFv h(FcεRIγ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-FcεRIγ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-1-M329-Z Anti-CS1 scFv h(CD3ζ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M329-2Z Anti-CS1 scFv h(CD28-CD3ζ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD28-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M329-4G Anti-CS1 scFv h(CD4-FcεRIγ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD4-FcεRIγ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M329-4Z Anti-CS1 scFv h(CD4-CD3ζ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD4-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M329-8Z Anti-CS1 scFv h(CD8-CD3ζ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD8-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M329-BG Anti-CS1 scFv h(CD28-FcεRIγ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD28-FcεRIγ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M329-BZ Anti-CS1 scFv h(41BB-CD3ζ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-41BB-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-2-M329-CZ Anti-CS1 scFv h(b2c-CD3ζ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-b2c-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-NK-3-M329-2BZ Anti-CS1 scFv h(CD28-41BB-CD3ζ) CARNK, pCDCAR1 Human Luc90 Mouse scFv-CD28-41BB-CD3ζ Lentiviral NK cell   Add to Cart   Datasheet
CAR-LC302 Anti-SLAMF7 (Luc63) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 Human Luc63 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC303 Anti-SLAMF7 (Luc63) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 Human Luc63 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC304 Anti-SLAMF7 (Luc90) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 Human Luc90 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC305 Anti-SLAMF7 (Luc90) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 Human Luc90 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC306 Anti-SLAMF7 (Luc34) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 Human Luc34 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC307 Anti-SLAMF7 (Luc34) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 Human Luc34 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC308 Anti-SLAMF7 (LucX1) h(41BB/CD3ζ) Multi-chain CAR, pCDCAR1 Human LucX1 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-41BB/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC309 Anti-SLAMF7 (LucX1) h(CD28/CD3ζ) Multi-chain CAR, pCDCAR1 Human LucX1 Mouse FcεR1α-SP-scFv/FcεR1β-ΔITAM-CD28/FcεR1γ-SP-ΔITAM-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC365 Anti-SLAMF7×FN1 h(CD28-41BB-CD3ζ, cMYCmu) Dual CAR, pCDCAR1 Human Luc63 Mouse scFv (SLAMF7)-CD28-41BB-CD3ζ/scFv (FN)-cMYCmu Lentiviral T cell   Add to Cart   Datasheet
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