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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
DNAM-1 (DNAX Accessory Molecule-1) also known as CD226 (Cluster of Differentiation 226) or PTA1, is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAX accessory molecule-1 (DNAM-1), plays an important role in the NK cell-mediated recognition and killing of Multiple myeloma cells. Tumor cells can express DNAX-1 ligands. Recently, scientists have identified the poliovirus receptor (PVR) CD155 and its family member CD112 (PVRrelated family 2 [PRR-2], also called as nectin-2), as the ligands for human DNAM-1. Although the human DNAM-1 ligands CD112 and CD155 are broadly distributed on epithelial and endothelial cells in many tissues, they are overexpressed on certain human tumors, including colorectal carcinomas, myeloid leukemias,14 and neuroblastomas, suggesting that the expression of DNAM-1 ligands is inducible by "stress" such as transformation and infection.
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-MZ224 | Anti-DNAM-1 ligands, DNAM-1 h(CD3ζ) CAR, pCDCAR1 | Murine | DNAM-1-CD3ζ | Lentiviral | T cell | ||||
| CAR-MZ225 | Anti-DNAM-1 ligands, DNAM-1 h(CD28-CD3ζ) CAR, pCDCAR1 | Murine | DNAM-1-CD28-CD3ζ | Lentiviral | T cell | ||||
| CAR-MZ226 | Anti-DNAM-1 ligands, DNAM-1 h(OX40-CD3ζ) CAR, pCDCAR1 | Murine | DNAM-1-OX40-CD3ζ | Lentiviral | T cell | ||||
| CAR-MZ227 | Anti-DNAM-1 ligands, DNAM-1 h(41BB-CD3ζ) CAR, pCDCAR1 | Murine | DNAM-1-41BB-CD3ζ | Lentiviral | T cell | ||||
| CAR-MZ228 | Anti-DNAM-1 ligands, DNAM-1 h(CD28TM-CD28-CD3ζ) CAR, pCDCAR1 | Murine | DNAM-1-CD28TM-CD28-CD3ζ | Lentiviral | T cell |
NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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