E6

Human papillomavirus is a DNA virus from the papillomavirus family, of which over 150 types are known. More than 40 types are transmitted through sexual contact and infect the anus and genitals. HPV is typically spread by sustained direct skin-to-skin contact with vaginal and anal sex being the most common methods.Protein E6 plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Associated Disease
  • Human papillomavirus infection

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C042Z E6 HPV16 24.101 Human ~8kb Lentiviral aa 73-104 Codon-modified and cysteinized HLA-DP1 Inquiry
TCR-C043Z E6 HPV16 Murinized ~8kb Lentiviral aa 29-38 Murinized HLA-A*0201 Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C104 HPV16 24.101 Human Lentivirus aa 73-104 Codon-modified and cysteinized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C105 HPV16 Murinized Lentivirus aa 29-38 Murinized TCR > 10⁷ IFU/ml Inquiry
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