Epidermal growth factor receptor (EGFR) is a transmembrane protein that is activated by binding of its specific ligands. Epidermal growth factor receptor isoform (EGFRvA) has higher tumor-promoting capacity than EGFR. Moreover, EGFRvA is more stable than EGFR because of its decreased binding to E3 ubiquitin ligase c-CbI. EGFRvA as a drug target is associated with lung cancer, colon cancer, anal cancer, glioblastoma and epithelian tumors of the head and neck.

Associated Disease
  • Lung cancer
  • Colon cancer
  • Anal cancer
  • Glioblastoma
  • Epithelian tumors of the head and neck
  • Others
  • CAR Vector Products
  • CAR Viral Particles
CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type  
CAR-MZ187 Anti-EGFRvA (2D3) h(CD3ζ) CAR, pCDCAR1 Human 2D3 Mouse scFv-CD3ζ Lentiviral T cell   Inquiry
CAR-MZ188 Anti-EGFRvA (2D3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2D3 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Inquiry
CAR-MZ189 Anti-EGFRvA (2D3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2D3 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
CAR-MZ190 Anti-EGFRvA (2D3) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human 2D3 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Inquiry

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