EGFRvA

Epidermal growth factor receptor (EGFR) is a transmembrane protein that is activated by binding of its specific ligands. Epidermal growth factor receptor isoform (EGFRvA) has higher tumor-promoting capacity than EGFR. Moreover, EGFRvA is more stable than EGFR because of its decreased binding to E3 ubiquitin ligase c-CbI. EGFRvA as a drug target is associated with lung cancer, colon cancer, anal cancer, glioblastoma and epithelian tumors of the head and neck.

Associated Disease
  • Lung cancer
  • Colon cancer
  • Anal cancer
  • Glioblastoma
  • Epithelian tumors of the head and neck
  • Others

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-MZ187 T cell First 2D3 ~8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-MZ188 T cell Second 2D3 ~8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-MZ189 T cell Second 2D3 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-MZ190 T cell Third 2D3 ~8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC877 2D3 Lentivirus First scFv (2D3)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC878 2D3 Lentivirus Second scFv (2D3)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC879 2D3 Lentivirus Second scFv (2D3)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC880 2D3 Lentivirus Third scFv (2D3)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

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Australia
australia

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