F13A1

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This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP69 F13A1 (ITGA4 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human F13A1-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP70 F13A1 (ITGA9 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human F13A1-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP71 F13A1 (ITGB1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human F13A1-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1469 F13A1 (ITGA4 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human F13A1-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1470 F13A1 (ITGA9 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human F13A1-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1471 F13A1 (ITGB1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human F13A1-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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