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FEN1

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The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ0889 Anti-FEN1 (CBXF-0492) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0492 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0890 Anti-FEN1 (CBXF-1192) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXF-1192 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0891 Anti-FEN1 (CBXF-2399) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXF-2399 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0892 Anti-FEN1 (4E7) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse 4E7 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0893 Anti-FEN1 (CBXF-3553) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-3553 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0894 Anti-FEN1 (2357C3a) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2357C3a Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0895 Anti-FEN1 (CBXF-0489) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0489 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0896 Anti-FEN1 (CBXF-0490) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0490 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0897 Anti-FEN1 (CBXF-0491) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0491 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0898 Anti-FEN1 (CBXF-0493) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXF-0493 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0899 Anti-FEN1 (CBXF-0494) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXF-0494 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0900 Anti-FEN1 (CBXF-3463) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat, Monkey, Hamster CBXF-3463 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0901 Anti-FEN1 (CBXF-0495) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0495 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0902 Anti-FEN1 (CBXF-2945) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-2945 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0903 Anti-FEN1 (CBXF-2946) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXF-2946 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4313 Anti-FEN1 (CBXF-0492) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXF-0492 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4314 Anti-FEN1 (CBXF-1192) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXF-1192 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4315 Anti-FEN1 (CBXF-2399) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXF-2399 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4316 Anti-FEN1 (4E7) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse 4E7 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4317 Anti-FEN1 (CBXF-3553) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXF-3553 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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