This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Associated Disease
  • Diabetes mellitus
  • TCR Vector Products
  • TCR Viral Particles
  • Vector Type:
CAT Product Name Target Species TCR Clone Host Species Epitope Allele Vector Type Inquiry & Datasheet
TCR-L022 Human anti-GAD2 [286–300] T Cell Receptor, pMSGV1 Human Human GAD65[286–300] retroviral vector   Add to Cart   Datasheet
TCR-L022Z Human anti-GAD65 (aa286–300) T cell receptor, pCDTCR1 Human Human GAD65[286–300] Lentiviral   Add to Cart   Datasheet

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