GAD65

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Associated Disease
  • Diabetes mellitus

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-L022 GAD65 Human Human 6700-8070bp retroviral vector GAD65[286–300] Non-modified TCR Inquiry
TCR-L022Z GAD65 Human Human 8kb Lentiviral GAD65[286–300] Non-modified Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C145 Human Human Lentivirus GAD65[286–300] Non-modified TCR > 10⁷ IFU/ml Inquiry
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