General Control Protein GCN4, is a transcription factor for over 30 genes necessary for amino acid or purine biosynthesis in the case of amino acid or purine starvation. As a transcription factor located in the nucleus, GCN4 regulates many genes connected to purine biosynthesis, autophagy, multiple stress responses, glycogen homeostasis, and organelle biosynthesis. A specific antibody conjugated to GCN4 peptide can be used to redirect the activity of the CAR-T cells to antigen expressing cancer cells.
|CAT||Product Name||Target Species||Antibody Clone||Antibody Host||Receptor Construction||Vector Type||Targeting Cell Type|
|CAR-LC281||Anti-GCN4 (52SR4) h(41BB-CD3ζ, GCN4 (52SR4)) Conditional CAR, pCDCAR1||52SR4||Mouse||scFv-41BB-CD3ζ||Lentiviral||T cell|
Nanoparticle Tiny Tech for Programming T Cells: A novel technology to increase the efficiency and value of your CAR-T therapy project.LEARN MORE
End-to-end CAR Hybrid TCR (CHyT)-T Cell Therapy Development Services: A novel solution to engineer T cell to be a promising cellular therapy with the complete TCR without HLA dependence.LEARN MORE
TRAC-CAR-T Cell Development with CRISPR/Cas9 Technology: A novel technology to build more powerful CAR-T cells.LEARN MORE