General Control Protein GCN4, is a transcription factor for over 30 genes necessary for amino acid or purine biosynthesis in the case of amino acid or purine starvation. As a transcription factor located in the nucleus, GCN4 regulates many genes connected to purine biosynthesis, autophagy, multiple stress responses, glycogen homeostasis, and organelle biosynthesis. A specific antibody conjugated to GCN4 peptide can be used to redirect the activity of the CAR-T cells to antigen expressing cancer cells.

Associated Disease
  • CAR Vector Products
CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type  
CAR-LC281 Anti-GCN4 (52SR4) h(41BB-CD3ζ, GCN4 (52SR4)) Conditional CAR, pCDCAR1 52SR4 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Inquiry

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