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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
General Control Protein GCN4, is a transcription factor for over 30 genes necessary for amino acid or purine biosynthesis in the case of amino acid or purine starvation. As a transcription factor located in the nucleus, GCN4 regulates many genes connected to purine biosynthesis, autophagy, multiple stress responses, glycogen homeostasis, and organelle biosynthesis. A specific antibody conjugated to GCN4 peptide can be used to redirect the activity of the CAR-T cells to antigen expressing cancer cells.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC281 | Anti-GCN4 (X8LX1) h(41BB-CD3ζ, GCN4 (X8LX1)) Conditional CAR, pCDCAR1 | Human | X8LX1 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| XS-0922-LX10 | Anti-GCN4 (X9X10) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-LX11 | Anti-GCN4 (X9X11) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-LX209 | Anti-GCN4 (X9X10) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-LX210 | Anti-GCN4 (X9X11) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-CD28-OX40-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-LX408 | Anti-GCN4 (X9X10) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-LX409 | Anti-GCN4 (X9X11) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-ICOS-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| XS-0922-LX607 | Anti-GCN4 (X9X10) Negative Control CAR, pCDCAR1 | Human | X9X10 | Mouse | scFv-CD28/CD8TM | Lentiviral vector | T cell | ||
| XS-0922-LX608 | Anti-GCN4 (X9X11) Negative Control CAR, pCDCAR1 | Human | X9X11 | Mouse | scFv-CD28/CD8TM | Lentiviral vector | T cell | ||
| XS-0823-LX50 | Anti-hGCN4 (mabb) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | mabb | Adenoviral vectors |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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