GCN4

General Control Protein GCN4, is a transcription factor for over 30 genes necessary for amino acid or purine biosynthesis in the case of amino acid or purine starvation. As a transcription factor located in the nucleus, GCN4 regulates many genes connected to purine biosynthesis, autophagy, multiple stress responses, glycogen homeostasis, and organelle biosynthesis. A specific antibody conjugated to GCN4 peptide can be used to redirect the activity of the CAR-T cells to antigen expressing cancer cells.

Associated Disease

CAR Vector Products Product list:

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Cell Type
Generation Antibody
Clone
Vector
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Vector
Type
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Host
Data
sheet
Price
CAR-LC281 T cell 52SR4 ~8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
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