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GDF5

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY0518 Anti-GDF5 (CBFYE-1452) h(41BB-CD3ζ) CAR, pCDCAR1 Rat CBFYE-1452 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY3771 Anti-GDF5 (CBFYE-1452) h(CD28-CD3ζ) CAR, pCDCAR1 Rat CBFYE-1452 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP688 GDF5 (BMPR1B Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human GDF5-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP689 GDF5 (BMPR2 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human GDF5-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP690 GDF5 (ROR2 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human GDF5-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2088 GDF5 (BMPR1B Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human GDF5-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2089 GDF5 (BMPR2 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human GDF5-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2090 GDF5 (ROR2 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human GDF5-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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