HA

Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A. Influenza virus A is a genus of the Orthomyxoviridae family of viruses. Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans. Occasionally, viruses are transmitted from wild aquatic birds to domestic poultry, and this may cause an outbreak or give rise to human influenza pandemics. Influenza A viruses are negative-sense, single-stranded, segmented RNA viruses. The several subtypes are labeled according to an H number (for the type of hemagglutinin) and an N number (for the type of neuraminidase). There are 18 different known H antigens (H1 to H18) and 11 different known N antigens (N1 to N11). H17 was isolated from fruit bats in 2012. H18N11 was discovered in a Peruvian bat in 2013. Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species. A filtered and purified influenza A vaccine for humans has been developed, and many countries have stockpiled it to allow a quick administration to the population in the event of an avian influenza pandemic. Avian influenza is sometimes called avian flu, and colloquially, bird flu. In 2011, researchers reported the discovery of an antibody effective against all types of the influenza A virus. Influenza haemagglutinin is a glycoprotein found on the surface of influenza viruses. It is responsible for binding the virus to cells with sialic acid on the membranes, such as cells in the upper respiratory tract or erythrocytes. It is also responsible for the fusion of the viral envelope with the endosome membrane, after the pH has been reduced. The name "hemagglutinin" comes from the protein's ability to cause red blood cells to clump together in vitro. Influenza haemagglutinin is a glycoprotein found on the surface of influenza viruses. It is responsible for binding the virus to cells with sialic acid on the membranes, such as cells in the upper respiratory tract or erythrocytes. It is also responsible for the fusion of the viral envelope with the endosome membrane, after the pH has been reduced. The name "hemagglutinin" comes from the protein's ability to cause red blood cells to clump together in vitro.

Associated Disease
  • Influenza

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-C090Z HA IAV HA1.7 Human ~8kb Lentiviral PKYVKQNTLKLAT Non-modified HLA-DR4 Inquiry
TCR-C091Z HA IAV scTCR-T7 Mouse ~8kb Lentiviral PKYVKQNTLKLAT Single-chain HLA-DR1 Inquiry
TCR-C092Z HA IAV HA1.7 Murinized ~8kb Lentiviral aa 307-319 Murinized HLA-DR4 Inquiry
TCR-C236Z HA IAV 14.3.d Mouse ~8kb Lentiviral aa 110-120 Single-chain I-Ed  Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C176 IAV HA1.7 Human Lentivirus PKYVKQNTLKLAT Non-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C177 IAV scTCR-T7 Mouse Lentivirus PKYVKQNTLKLAT Single-chain TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C178 IAV HA1.7 Murinized Lentivirus aa 307-319 Murinized TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C179 IAV 14.3.d Mouse Lentivirus aa 110-120 Single-chain TCR > 10⁷ IFU/ml Inquiry
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