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Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A. Influenza virus A is a genus of the Orthomyxoviridae family of viruses. Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans. Occasionally, viruses are transmitted from wild aquatic birds to domestic poultry, and this may cause an outbreak or give rise to human influenza pandemics. Influenza A viruses are negative-sense, single-stranded, segmented RNA viruses. The several subtypes are labeled according to an H number (for the type of hemagglutinin) and an N number (for the type of neuraminidase). There are 18 different known H antigens (H1 to H18) and 11 different known N antigens (N1 to N11). H17 was isolated from fruit bats in 2012. H18N11 was discovered in a Peruvian bat in 2013. Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species. A filtered and purified influenza A vaccine for humans has been developed, and many countries have stockpiled it to allow a quick administration to the population in the event of an avian influenza pandemic. Avian influenza is sometimes called avian flu, and colloquially, bird flu. In 2011, researchers reported the discovery of an antibody effective against all types of the influenza A virus. Influenza haemagglutinin is a glycoprotein found on the surface of influenza viruses. It is responsible for binding the virus to cells with sialic acid on the membranes, such as cells in the upper respiratory tract or erythrocytes. It is also responsible for the fusion of the viral envelope with the endosome membrane, after the pH has been reduced. The name "hemagglutinin" comes from the protein's ability to cause red blood cells to clump together in vitro. Influenza haemagglutinin is a glycoprotein found on the surface of influenza viruses. It is responsible for binding the virus to cells with sialic acid on the membranes, such as cells in the upper respiratory tract or erythrocytes. It is also responsible for the fusion of the viral envelope with the endosome membrane, after the pH has been reduced. The name "hemagglutinin" comes from the protein's ability to cause red blood cells to clump together in vitro.

Associated Disease
  • Influenza
  • TCR Vector Products
  • TCR Viral Particles
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CAT Product Name Target SpeciesAntibody CloneAntibody HostEpitopeHLAVector Type Inquiry & Datasheet
TCR-C090Z Human anti-HA T cell receptor (HA1.7), pCDTCR1 IAV HA1.7 Human PKYVKQNTLKLAT HLA-DR4 Lentiviral   Add to Cart   Datasheet
TCR-C091Z Mouse anti-HA T cell receptor (scTCR-T7), pCDTCR1 IAV scTCR-T7 Mouse PKYVKQNTLKLAT HLA-DR1 Lentiviral   Add to Cart   Datasheet
TCR-C092Z Murinized anti-HA T cell receptor (HA1.7), pCDTCR1 IAV HA1.7 Murinized aa 307-319 HLA-DR4 Lentiviral   Add to Cart   Datasheet
TCR-C236Z Mouse anti-HA T cell receptor (14.3.d), pCDTCR1 IAV 14.3.d Mouse aa 110-120 I-Ed  Lentiviral   Add to Cart   Datasheet

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