Human endogenous retroviruses (HERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They comprise up to 8% of the human genome. HERV-K is the most active ERV family in human genome. It is demonstrated that type 1 HERV-K envelope (env) transcripts are expressed in most human breast cancers, but not in normal breast tissues.
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