HLA-C

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP727 HLA-C (KIR2DL1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human HLA-C-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP728 HLA-C (KIR2DL3 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human HLA-C-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP729 HLA-C (KIR2DS4 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human HLA-C-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2127 HLA-C (KIR2DL1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human HLA-C-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2128 HLA-C (KIR2DL3 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human HLA-C-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2129 HLA-C (KIR2DS4 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human HLA-C-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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