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IAV PA

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.
  • TCR Cell Products

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CAT Product Name Cell Type Target HLA Epitope Inquiry & Datasheet
TCRJ-CQ281 Anti-IAV PA (SSLENFRAYV) T Cell Receptor (clone 6218), Jurkat Cell Line T lymphocyte IAV PA H-2Db SSLENFRAYV   Add to Cart   Datasheet
XS-0623-ZP167 Anti-IAV PA TCR-NK Cells TCR-NK IAV PA   Add to Cart   Datasheet
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