KISS1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP883 KISS1 (KISS1R Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human KISS1-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2283 KISS1 (KISS1R Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human KISS1-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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