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L1 cell adhesion molecule(L1-CAM), also known as L1, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1, is encoded by the L1CAM gene, which is a transmembrane protein member of the L1 protein family. By the expression in neural, hematopoietic and transformed epithelial cells, this neuronal cell adhesion molecule playing a role in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation. L1-CAM expression promotes invasiveness of the tumor as well as chemoresistance, which is related to ovarian cancer, colon cancer, glioma, renal cell cancer, neuroblastoma, endometrial cancer, melanoma, pancreatic cancer.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC259 | Anti-CE7 h(CD3ζ) CAR, pCDCAR1 | Human | Mouse | scFv-CD3ζ | Retroviral | T cell |
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