L1 cell adhesion molecule (L1-CAM)

L1 cell adhesion molecule(L1-CAM), also known as L1, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1, is encoded by the L1CAM gene, which is a transmembrane protein member of the L1 protein family. By the expression in neural, hematopoietic and transformed epithelial cells, this neuronal cell adhesion molecule playing a role in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation. L1-CAM expression promotes invasiveness of the tumor as well as chemoresistance, which is related to ovarian cancer, colon cancer, glioma, renal cell cancer, neuroblastoma, endometrial cancer, melanoma, pancreatic cancer.

Associated Disease
  • CAR Vector Products
  • CAR Viral Particles
CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type  
CAR-MZ195 Anti-L1-CAM (CE7) h(CD3ζ) CAR, pCDCAR1 Human CE7 Mouse scFv-CD3ζ Lentiviral T cell   Inquiry
CAR-MZ196 Anti-L1-CAM (CE7) h(CD28-CD3ζ) CAR, pCDCAR1 Human CE7 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Inquiry
CAR-MZ197 Anti-L1-CAM (CE7) h(41BB-CD3ζ) CAR, pCDCAR1 Human CE7 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
CAR-LC259 Anti-CE7 h(CD3ζ) CAR, pCDCAR1 Human Mouse scFv-CD3ζ Retroviral T cell   Inquiry

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