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LAMC2

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. LAMC2 is the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. Among its related pathways are ERK Signaling and Focal Adhesion.

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-YJ032 Anti-LAMC2 (CL2980) h(41BB-CD3ζ) CAR, pCDCAR1 Human CL2980 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ532 Anti-LAMC2 (CL2980) h(CD28-CD3ζ) CAR, pCDCAR1 Human CL2980 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP898 LAMC2 (ITGA3 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP899 LAMC2 (ITGA6 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP900 LAMC2 (ITGB1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP901 LAMC2 (ITGB4 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2298 LAMC2 (ITGA3 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2299 LAMC2 (ITGA6 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2300 LAMC2 (ITGB1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2301 LAMC2 (ITGB4 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human LAMC2-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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