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LIMK1

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There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. LIMK1 also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Diseases associated with LIMK1 include Williams-Beuren Syndrome and Supravalvular Aortic Stenosis. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Apoptotic Pathways in Synovial Fibroblasts.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-YJ081 Anti-LIMK1 (1A8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1A8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ082 Anti-LIMK1 (1B2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1B2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ083 Anti-LIMK1 (1F1) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1F1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ084 Anti-LIMK1 (2A11) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2A11 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ085 Anti-LIMK1 (2E9) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2E9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ086 Anti-LIMK1 (3A3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3A3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ087 Anti-LIMK1 (3G3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3G3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ088 Anti-LIMK1 (3H6) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat, Monkey 3H6 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ089 Anti-LIMK1 (6A7) h(41BB-CD3ζ) CAR, pCDCAR1 Human 6A7 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ090 Anti-LIMK1 (6B4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 6B4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ091 Anti-LIMK1 (7C3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 7C3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ092 Anti-LIMK1 (8B2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 8B2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ093 Anti-LIMK1 (8C8) h(41BB-CD3ζ) CAR, pCDCAR1 Human 8C8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ581 Anti-LIMK1 (1A8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1A8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ582 Anti-LIMK1 (1B2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1B2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ583 Anti-LIMK1 (1F1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1F1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ584 Anti-LIMK1 (2A11) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2A11 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ585 Anti-LIMK1 (2E9) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2E9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ586 Anti-LIMK1 (3A3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3A3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ587 Anti-LIMK1 (3G3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3G3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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