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MAP3K4

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The central core of each mitogen-activated protein kinase pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase phosphorylates and activates a specific MAPK kinase , which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY1927 Anti-MAP3K4 (CBFYM-0505) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYM-0505 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY1928 Anti-MAP3K4 (CBFYM-1531) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYM-1531 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY1929 Anti-MAP3K4 (CBFYM-1532) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse, Human CBFYM-1532 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5180 Anti-MAP3K4 (CBFYM-0505) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYM-0505 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5181 Anti-MAP3K4 (CBFYM-1531) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYM-1531 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5182 Anti-MAP3K4 (CBFYM-1532) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Human CBFYM-1532 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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