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MDC1

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The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
  • CAR Vector Products

  • DMAb

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY2094 Anti-MDC1 (P2B11) h(41BB-CD3ζ) CAR, pCDCAR1 Cow, Human, Mouse P2B11 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2095 Anti-MDC1 (CBFYM-1934) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYM-1934 Rat scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2096 Anti-MDC1 (CBFYM-1935) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Monkey CBFYM-1935 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5347 Anti-MDC1 (P2B11) h(CD28-CD3ζ) CAR, pCDCAR1 Cow, Human, Mouse P2B11 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5348 Anti-MDC1 (CBFYM-1934) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYM-1934 Rat scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5349 Anti-MDC1 (CBFYM-1935) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Monkey CBFYM-1935 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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