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MECP2

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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain. Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY2139 Anti-MECP2 (8H4A5B9) h(41BB-CD3ζ) CAR, pCDCAR1 Human 8H4A5B9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2140 Anti-MECP2 (CBFYM-1988) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYM-1988 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2141 Anti-MECP2 (CBFYM-1989) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat, Monkey CBFYM-1989 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2142 Anti-MECP2 (CBFYM-1990) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBFYM-1990 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY2143 Anti-MECP2 (CBFYM-1991) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human, Fruit Fly CBFYM-1991 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5392 Anti-MECP2 (8H4A5B9) h(CD28-CD3ζ) CAR, pCDCAR1 Human 8H4A5B9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5393 Anti-MECP2 (CBFYM-1988) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBFYM-1988 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5394 Anti-MECP2 (CBFYM-1989) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat, Monkey CBFYM-1989 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5395 Anti-MECP2 (CBFYM-1990) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBFYM-1990 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5396 Anti-MECP2 (CBFYM-1991) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human, Fruit Fly CBFYM-1991 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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