NODAL

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP950 NODAL (ACVR1B Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP951 NODAL (ACVR1C Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP952 NODAL (ACVR2A Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP953 NODAL (ACVR2B Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2350 NODAL (ACVR1B Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2351 NODAL (ACVR1C Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2352 NODAL (ACVR2A Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2353 NODAL (ACVR2B Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human NODAL-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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