NS3-4A protein

HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV has four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B). NS5A is a hydrophilic phosphoprotein which plays an important role in viral replication, modulation of cell signaling pathways and the interferon response. It is known to bind to endoplasmic reticulum anchored human VAP proteins.

Associated Disease
  • HCV infection
  • TCR Vector Products
  • TCR Viral Particles
CAT Product Name Target Species Antibody Clone Antibody Host Epitope HLA Vector Type  
TCR-C184Z Human anti-NS3-4A protein T cell receptor (DD31), pCDTCR1 HCV DD31 Human HSKKKCDEL HLA-B*0801 Lentiviral   Inquiry

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