Anti-PA TCR Products - Creative Biolabs

Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.

Associated Disease

Influenza

Vector Products
Viral Particles

TCR Vector Products Product list:

Catalog	Target	Target Species	Antibody Clone	scFv-Host Animal	Vector length	Vector Type	Epitope	Format	HLA	Data sheet	Price
TCR-C207Z	PA	IAV	6218	Chimeric	~8kb	Lentiviral	SSLENFRAYV	Chimeric	HLA-DB		Inquiry

TCR Viral Particles Product list:

Catalog	Target Species	Antibody Clone	scFv-Host Animal	Packaging System	Epitope	Format	Titer	Data sheet	Price
VP-TCR-C365	IAV	6218	Chimeric	Lentivirus	SSLENFRAYV	Chimeric TCR	> 10⁷ IFU/ml		Inquiry

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