SEMA6D

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP191 SEMA6D (TREM2 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP192 SEMA6D (TYROBP Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1145 SEMA6D (KDR Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1146 SEMA6D (PLXNA1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1591 SEMA6D (TREM2 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1592 SEMA6D (TYROBP Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2545 SEMA6D (KDR Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2546 SEMA6D (PLXNA1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SEMA6D-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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