SHH

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This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP196 SHH (GPC5 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP197 SHH (LRP2 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1153 SHH (BOC Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1154 SHH (CDON Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1155 SHH (HHIP Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1156 SHH (PTCH1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1157 SHH (SMO Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1596 SHH (GPC5 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1597 SHH (LRP2 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2553 SHH (BOC Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2554 SHH (CDON Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2555 SHH (HHIP Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2556 SHH (PTCH1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2557 SHH (SMO Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human SHH-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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