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SMN1

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This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ2643 Anti-SMN1 (CBXS-5859) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-5859 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2644 Anti-SMN1 (CBXS-4368) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, African clawed frog CBXS-4368 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2645 Anti-SMN1 (CBXS-4567) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Non-human primate CBXS-4567 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2646 Anti-SMN1 (CBXS-4752) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXS-4752 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2647 Anti-SMN1 (CBXS-4992) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXS-4992 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2648 Anti-SMN1 (CBXS-5056) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-5056 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2649 Anti-SMN1 (CBXS-5191) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Non-human primate CBXS-5191 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2650 Anti-SMN1 (CBXS-0562) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-0562 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2651 Anti-SMN1 (CBXS-0563) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXS-0563 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2652 Anti-SMN1 (CBXS-2453) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Monkey CBXS-2453 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2653 Anti-SMN1 (CBXS-2454) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Monkey CBXS-2454 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2654 Anti-SMN1 (CBXS-3485) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, African clawed frog CBXS-3485 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ2655 Anti-SMN1 (SCB3) h(41BB-CD3ζ) CAR, pCDCAR1 Human SCB3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6067 Anti-SMN1 (CBXS-5859) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-5859 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6068 Anti-SMN1 (CBXS-4368) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, African clawed frog CBXS-4368 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6069 Anti-SMN1 (CBXS-4567) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Non-human primate CBXS-4567 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6070 Anti-SMN1 (CBXS-4752) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXS-4752 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6071 Anti-SMN1 (CBXS-4992) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat CBXS-4992 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6072 Anti-SMN1 (CBXS-5056) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXS-5056 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ6073 Anti-SMN1 (CBXS-5191) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Non-human primate CBXS-5191 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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