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TOSO, also known as Fas-inhibitory molecule 3 (FAIM3) or Fc mu receptor (FCMR) in humans is encoded by the FCMR gene. FCMR
was defined as a 60-kD transmembrane sialoglycoprotein and FCMR (TOSO) expression was up-regulated on B cells, but was down-modulated on T cells, suggesting differential regulation of TOSO expression during B and T cell activation. Human FCMR mRNA was strongly
expressed in hematopoietic tissues such as the spleen, thymus and peripheral blood leukocytes. Intracellular upregulation of Fc mu receptor (FCMR, FAIM3/TOSO) gene in the leukemic lymphocytes of the patients with CLL may be an important parameter in predicting the progression of the disease.
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC125 | Anti-TOSO (6B10) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 6B10 | Rat | scFv-CD28-CD3ζ | Retroviral | T cell | ||
| CAR-MV-01LX069 | Anti-TOSO (1 E4) h(CD28-CD3ζ) CAR, pMMLV | Human | 1 E4 | Mouse | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX070 | Anti-TOSO (#1389) h(CD28-CD3ζ) CAR, pMMLV | Human | #1389 | Human | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX071 | Anti-TOSO (2F5) h(CD28-CD3ζ) CAR, pMMLV | Human | 2F5 | Mouse | scFv-CD28-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX314 | Anti-TOSO (1 E4) h(41BB-CD3ζ) CAR, pMMLV | Human | 1 E4 | Mouse | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX315 | Anti-TOSO (#1389) h(41BB-CD3ζ) CAR, pMMLV | Human | #1389 | Human | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-MV-01LX316 | Anti-TOSO (2F5) h(41BB-CD3ζ) CAR, pMMLV | Human | 2F5 | Mouse | scFv-41BB-CD3ζ | Recombinant Moloney murine leukemia virus (MMLV) retroviral vector | T cell | ||
| CAR-SB-02LX066 | Anti-TOSO (1 E4) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | 1 E4 | Mouse | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX067 | Anti-TOSO (#1389) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | #1389 | Human | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX068 | Anti-TOSO (2F5) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | 2F5 | Mouse | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX310 | Anti-TOSO (2F5) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | 2F5 | Mouse | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| XS-0323-LX3864 | TRAC-TOSO (X3XT66) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT66 | Mouse | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX3865 | TRAC-TOSO (X3XT67) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT67 | Human | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX3866 | TRAC-TOSO (X3XT68) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT68 | Mouse | Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4106 | TRAC-TOSO (X3XT66) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT66 | Mouse | Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4107 | TRAC-TOSO (X3XT67) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT67 | Human | Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4108 | TRAC-TOSO (X3XT68) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT68 | Mouse | Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4348 | TRAC-TOSO (X3XT66) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT66 | Mouse | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4349 | TRAC-TOSO (X3XT67) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT67 | Human | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0323-LX4350 | TRAC-TOSO (X3XT68) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector | Human | X3XT68 | Mouse | Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm | Nonviral | T cell | CAR-T | |
| XS-0823-LX90 | Anti-hTOSO (ab) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector | Human | ab | Adenoviral vectors |
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