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Trop2

Tumor-associated calcium signal transducer 2 (Trop2) is a protein in humans is encoded by the TACSTD2 gene. Trop2 was first discovered in trophoblast cells. It is a transmembrane type-1 glycoprotein expressed in multistratified epithelia and several stem/progenitor and carcinoma cells. Trop2 could form an analogous dimer. The incomplete or aberrant production of Trop2 may cause it to lose its function and to be internalized from the membrane into the cytoplasm, where it plays a role in cancer progression. Due to elevated expression levels in carcinoma cells vs. normal tissue, Trop2 has clinical potential both for cancer prognosis and immunotherapy.

Associated Disease
  • CAR Vector Products
  • CAR Viral Particles
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  • Receptor Construction:
  • Vector Type:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-LC190 Anti-Trop2 h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-YF032 Anti-Trop2 (HRS) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human HRS Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YF033 Anti-Trop2 (HRS) h(CD28-CD3ζ) CAR, pCDCAR1 Human HRS Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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