TUBA1A

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A is an alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. TUBA1A is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-YJ409 Anti-TUBA1A (DM1A) h(41BB-CD3ζ) CAR, pCDCAR1 Chicken, Human, Cattle, Guinea pig, Mouse, Pig, Rat, Xenopus DM1A Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ410 Anti-TUBA1A (2D2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2D2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ411 Anti-TUBA1A (2C8) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Dog, Rat, Monkey, Mouse 2C8 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ909 Anti-TUBA1A (DM1A) h(CD28-CD3ζ) CAR, pCDCAR1 Chicken, Human, Cattle, Guinea pig, Mouse, Pig, Rat, Xenopus DM1A Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ910 Anti-TUBA1A (2D2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2D2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ911 Anti-TUBA1A (2C8) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Dog, Rat, Monkey, Mouse 2C8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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