VivoCAR™ Anti-FLT3 (EB10) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX111)

Name: VivoCAR™ Anti-FLT3 (EB10) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX111
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-FLT3 (EB10) h(CD28-41BB-CD3z) CAR circRNA utilizes the high-affinity EB10 clone to target the extracellular domain of FLT3 in acute myeloid leukemia. For in vivo applications, this product is pivotal for eliminating the aggressive FLT3-ITD+ sub-clones that drive rapid relapse. The circRNA platform delivers a transient therapeutic surge of CAR expression, enabling a potent "hit-and-run" depletion of leukemic blasts. This approach is safer than viral methods, as it avoids permanent bone marrow aplasia by ensuring the therapy naturally tapers off, allowing normal hematopoietic recovery to resume.

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Target Information

Target
FLT3

Common Name
FLT3

Alternative Names
CD135, FLK-2, FLK2, STK1

Full Name
FMS Related Receptor Tyrosine Kinase 3

Introduction
FLT3 is a critical receptor tyrosine kinase widely expressed on hematopoietic stem cells and progenitor cells. It is one of the most important targets in Acute Myeloid Leukemia (AML), as it is highly expressed on leukemic blasts and, importantly, is frequently subject to activating mutations (e.g., FLT3-ITD) that drive the malignancy. Targeting FLT3 with CAR-T cells is a strategy aimed at eliminating AML blasts and the chemoresistant leukemic stem cell (LSC) population.

Targeting Diseases
Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS)

UniProt ID
P36888

Gene ID
2322

Target Species
Human

Antibody Clone
EB10

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-FLT3 (EB10) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX111)

Target Information

Customer Reviews and Q&As

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