SIRP Alpha
SIRP alpha is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons. SIRP alpha acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47. This interaction negatively controls effector function of innate immune cells such as host cell phagocytosis. SIRP alpha diffuses laterally on the macrophage membrane and accumulates at a phagocytic synapse to bind CD47 and signal 'self', which inhibits the cytoskeleton-intensive process of phagocytosis by the macrophage. This is analogous to the self signals provided by MHC class I molecules to NK cells via Ig-like or Ly49 receptors. NB. Protein shown to the right is CD47 not SIRP alpha.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr3847 | Recombinant SIRP alpha Protein (Met 1-Arg 370) [His] | Mammalian cells | Recombinant SIRP alpha Protein (Met 1-Arg 370) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45-50 kDa. (Uniprot ID: P78324) | SIRP alpha | Tumor Antigens |  |
100 µg | Inquiry |
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