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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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The vector of anti-CD7 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CD7. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD7 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of T-cell acute lymphocytic leukemia (T-ALL) .
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CAR Construction : 3A1e-41BB-CD3ζ
Fig.7 In vitro cytotoxicity of base-edited CD3CAR and CD7CAR cells. 51Cr labelled Jurkat T cells modified to express CD3+CD7+, CD3+CD7−, CD3−CD7+ or CD3−CD7− were co-cultured with either CD3CAR , CD7CAR , mixed CD3CAR/CD7CAR or untransduced cells at an increasing ratio of effectors:targets (E:T). Georgiadis, Christos, et al. "Base-edited CAR T cells for combinational therapy against T cell malignancies." Leukemia 35.12 (2021): 3466-3481. Distributed under Open Access license CC BY 4.0, without modification. |
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CAR Construction : 3A1e-41BB-CD3ζ
Fig.8 CD3CAR and CD7CAR T cells exhibit potent anti-leukaemic effects in vivo. CD3CAR or CD7CAR cells edited using either SpCas9 or coBE3 mRNA were infused intravenously on day 4 alongside PBS and untransduced controls and leukaemic progression was monitored by serial bioluminescent imaging on over four weeks. Georgiadis, Christos, et al. "Base-edited CAR T cells for combinational therapy against T cell malignancies." Leukemia 35.12 (2021): 3466-3481. Distributed under Open Access license CC BY 4.0, without modification. |
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