The vector of anti-CEACAM5 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CEACAM5. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CEACAM5 antibody linked to 4-1BB(CD137), OX40 and CD3ζ signaling domains. And the vector product was designed for the treatment of multiple myeloma.
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