All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-FLT3 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human FLT3. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-FLT3 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Acute lymphoblastic leukemia (ALL).
CAR Construction : Fig.1 Flow cytometry analysis of the FLT3 expression using anti-FLT3 CLONE 4G8. B-ALL cell lines were incubated with mouse anti-human FLT3 mAb clone 4G8. Schmied, B. J., Lutz, M. S., Riegg, F., Zekri, L., Heitmann, J. S., Bühring, H. J., ... & Salih, H. R. (2019). Induction of NK cell reactivity against B-cell acute lymphoblastic leukemia by an Fc-optimized FLT3 antibody. Cancers, 11(12), 1966. |
CAR Construction : Fig.2 Flow cytometry analysis of the FLT3 expression using anti-FLT3 CLONE 4G8. Cell surface expression of FLT3 in the AML cell lines EOL-1, MOLM-13, and MV4-11, and in the multiple myeloma cell line MOLP-8 was determined by flow cytometry analysis using a commercially available antibody (clone 4G8). Sommer, C., Cheng, H. Y., Nguyen, D., Dettling, D., Yeung, Y. A., Sutton, J., ... & Sasu, B. J. (2020). Allogeneic FLT3 CAR T cells with an off-switch exhibit potent activity against AML and can be depleted to expedite bone marrow recovery. Molecular Therapy, 28(10), 2237-2251. |
CAR Construction : Fig.3 Flow cytometry analysis of the FLT3 expression using anti-FLT3 CLONE 4G8. Cell surface expression of FLT3 on normal HSPCs was assessed by flow cytometry using an anti-FLT3 antibody (4G8) or an isotype control antibody. Sommer, C., Cheng, H. Y., Nguyen, D., Dettling, D., Yeung, Y. A., Sutton, J., ... & Sasu, B. J. (2020). Allogeneic FLT3 CAR T cells with an off-switch exhibit potent activity against AML and can be depleted to expedite bone marrow recovery. Molecular Therapy, 28(10), 2237-2251. |
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