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EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-HLA-DR chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human HLA-DR. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-HLA-DR antibody linked to CD28 and CD3ζ signaling domains.
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CAR Construction : huLym-1-B-41BB-CD3ζ
Fig.1 CAR-T cell viability. Percent viability measurement of subcultured 89Zr-oxine labeled and unlabeled huLym-1-A-BB3z-CAR T-cells on day 0, 1, 2, and 4 time points, respectively. Sta Maria, Naomi S., et al. "Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model." Scientific Reports 11.1 (2021): 15077. Distributed under Open Access license CC BY 4.0, without modification. |
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CAR Construction : huLym-1-B-41BB-CD3ζ
Fig.2 Cytokine release by CAR-transduced T cells. IL-2 and IFN-γ cytokines released by 89Zr-oxine labeled and unlabeled mock and huLym-1-A-BB3z-CAR T-cells. Sta Maria, Naomi S., et al. "Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model." Scientific Reports 11.1 (2021): 15077. Distributed under Open Access license CC BY 4.0, without modification. |
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CAR Construction : huLym-1-B-41BB-CD3ζ
Fig.3 Cytotoxicity assay in vitro. Cytotoxicity of 89Zr-oxine labeled and unlabeled mock and huLym-1-A-BB3z-CAR T-cells against Lym-1-positive Raji cells. Sta Maria, Naomi S., et al. "Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model." Scientific Reports 11.1 (2021): 15077. Distributed under Open Access license CC BY 4.0, without modification. |
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