Anti-IL6ST DNA-encoded mAb (DMAb), pVAX1 (DMAb-1401-YY)

Name: Anti-IL6ST DNA-encoded mAb (DMAb), pVAX1
SKU: DMAb-1401-YY
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-IL6ST DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
IL6ST

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
3572

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0165-YY	CBYY-0695	Mouse	Human	IgG2a	Recognizes the human CD130 cell surface antigen, a 130kD glycoprotein that is a part of cell surface receptor complexes for cytokines including IL-6, LIF, OSM and IL-11
DMAb-0166-YY	CBYY-0696	Mouse	Human	IgG1	Mouse myeloma cell line NS0-derived recombinant rat gp130 Gln23-Glu618 (predicted)
DMAb-3769CQ	CBXC-1864	Mouse		IgG1
DMAb-3770CQ	CBXC-1856	Mouse		IgG2a
DMAb-3771CQ	CBXC-1841	Mouse		IgG2b
DMAb-3772CQ	CBXC-1844	Mouse		IgG1
DMAb-3773CQ	CBXC-1853	Mouse		IgG1
DMAb-3994-FY	CBFYC-2777	Rat	Mouse	IgG2	Mouse recombinant protein gp-130
DMAb-3995-FY	CBFYC-2778	Rat	Mouse	IgG2a	Mouse myeloma cell line NS0-derived recombinant mouse gp130 Gln23-Glu617 (predicted)
DMAb-3996-FY	CBFYC-2779	Mouse	Human	IgG1	Recombinant human gp130 extracellular domain
DMAb-3511-FY	CBFYH-2594	Mouse	Human	IgG1
DMAb-3508-FY	CBFYH-2592	Rat	Mouse	IgG2a	Mouse myeloma cell line NS0-derived recombinant mouse gp130, Gln23-Glu617
DMAb-3504-FY	CBFYH-3280	Mouse	Human	IgG1	Human CD130
DMAb-3519-FY	CBFYH-2593	Mouse	Rat	IgG1	Mouse myeloma cell line NS0-derived recombinant rat gp130, Gln23-Glu618
DMAb-3631-FY	CBFYH-2590	Rat	Mouse	IgG2a	CD130 transfectant mouse cell
DMAb-3632-FY	CBFYH-2591	Mouse	Human	IgG1	Sf 21-derived recombinant human gp130 extracellular domain, Leu24-Glu619

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-IL6ST DNA-encoded mAb (DMAb), pVAX1 (DMAb-1401-YY)

Specifications

Target

Customer Reviews and Q&As

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