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Anti-KMT2D T cell receptor (BF11), pCDTCR1 (TCR-YC0620)

The vector of anti-KMT2D T cell receptor (TCR) is constructed for the engineering of T cell to target Lysine Methyltransferase 2D (ALSPVIPLI) restricted by HLA-A*02:01. The T cells are genetically modified through transduction with a lentiviral vector expressing KMT2D-specific T cell receptor.

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Details

  • Target
  • KMT2D
  • Target Species
  • Human
  • Epitope
  • ALSPVIPLI
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*02:01
  • Targeting Diseases
  • Kabuki syndrome
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • BF11
  • Host Species
  • Human

Target

  • Introduction
  • The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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