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Anti-Rac-1 T cell receptor (T6), pCDTCR1 (TCR-L219)

The vector of anti-Rac-1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human Rac-1. The T cells are genetically modified through transduction with a lentiviral vector expressing Rac-1-specific T cell receptor. And the vector product was designed for the treatment of Melanoma.

Details

  • Target
  • Rac-1
  • Target Species
  • Human
  • Epitope
  • FSGEHPTV
  • Format
  • Non-modified
  • HLA
  • HLA-A201
  • Targeting Diseases
  • Melanoma
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • T6
  • Antibody Host
  • Human

Target

  • Gene Name
  • ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1
  • Official Symbol
  • RAC1
  • Synonyms
  • SARS-CoV; SARS-CoV coronavirus; SARS-CoV; coronavirus; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; SARS
  • Introduction
  • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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