Name: Anti-MAGE-A1 (scfv) h(NKG2D-2B4-DAP10-CD3z) CAR-NK92 Cell Pool
SKU: XS-1125-LX60
Rating: 5 (1 reviews)

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CAR Information

Target
MAGE-A1

Common Name
Magea1

Full Name
Melanoma-associated antigen 1

Gene ID
4100

Introduction
A Cancer-Testis Antigen (CTA), normally only expressed in the testis. Its aberrant expression in melanoma and lung cancer makes it a potential target for TCR and CAR cell therapies.

UniProt ID
P48439

Alternative Names
Melanoma-associated antigen 1

Targeting Diseases
Cancer

Antibody Clone
scfv

scFv Host Species
Human

Hinge
CD8 or Others design, such as CD28

TM
CD8 or Others design, such as CD28

Marker
GFP or N/A

Discription of Signaling Cassetes
The h(NKG2D-2B4-DAP10-CD3z) chimeric antigen receptor (CAR) is a specialized construct designed to enhance the anti-tumor activity of engineered immune cells, particularly Natural Killer (NK) cells or T cells, by combining multiple signaling domains. The design is a third-generation CAR incorporating an antigen-binding domain derived from the native NKG2D receptor and multiple intracellular signaling domains.

Receptor Construction
h(NKG2D-2B4-DAP10-CD3z)
Other receptor construction also avilable, such as NKG2D-2B4-CD3z format; CD28-41BB-CD3z format, and so on.

Target Species
Human

Cell Type
NK92

Cell Background
The NK92 cell line is an immortalized human natural killer (NK) cell line used extensively in preclinical research and clinical trials for cancer immunotherapy, particularly in the development of chimeric antigen receptor (CAR)-NK cell therapies.

CAR Positive Rate
>70%

CAR Expression
Positive

Mycoplasma Testing
Negative

Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Safety Consideration
Biosafety Level 1

Restriction
Research use only

Size
2 million cells*2 vials

Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.