Close

Anti-latent membrane protein 2 LMP-2 T cell receptor, pCDTCR1 (TCR-L323)

The vector of anti-latent membrane protein 2 LMP-2 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV latent membrane protein 2 LMP-2. The T cells are genetically modified through transduction with a lentiviral vector expressing latent membrane protein 2 LMP-2-specific T cell receptor. And the vector product was designed for the treatment of EBV-associated disease.

Datasheet   Add to Cart

Details

  • Target
  • LMP2
  • Target Species
  • EBV
  • Epitope
  • CLGGLLTMV
  • Format
  • Non-modified
  • HLA
  • HLA-A0201
  • Targeting Diseases
  • EBV-associated disease
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • TCR Host Animal
  • Human

Target

  • Official Symbol
  • LMP-2
  • Introduction
  • Epstein–Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction.
Online Inquiry
Products

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:

Online Inquiry

For any technical issues or products/services related questions, please leave your contacts as below, and our team will contact you at earliest convenience to let you know how we can be involved in your projects.

  • Verification code
    Click image to refresh the verification code.

Key Updates

Receive the latest news and insights to your inbox.