Anti-latent membrane protein 2 LMP-2 T cell receptor, pCDTCR1(TCR-L323)

The vector of anti-latent membrane protein 2 LMP-2 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV latent membrane protein 2 LMP-2. The T cells are genetically modified through transduction with a lentiviral vector expressing latent membrane protein 2 LMP-2-specific T cell receptor. And the vector product was designed for the treatment of EBV-associated disease.


Details


Target
LMP2
Target Species
EBV
Epitope
CLGGLLTMV
Format
Non-modified
HLA
HLA-A0201
Targeting Diseases
EBV-associated disease
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Host
Human

Target


Gene Name
latent membrane protein 2
Official Symbol
LMP-2
Synonyms
Epstein–Barr virus latent membrane protein 2; latent membrane protein 2; LMP2; Epstein–Barr virus
Introduction
Epstein–Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-048-3343

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