Anti-latent membrane protein 2 LMP-2 T cell receptor, pCDTCR1 (TCR-L323)

The vector of anti-latent membrane protein 2 LMP-2 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV latent membrane protein 2 LMP-2. The T cells are genetically modified through transduction with a lentiviral vector expressing latent membrane protein 2 LMP-2-specific T cell receptor. And the vector product was designed for the treatment of EBV-associated disease.

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  • Target
  • LMP2
  • Target Species
  • EBV
  • Epitope
  • Format
  • Non-modified
  • Allele
  • HLA-A0201
  • Targeting Diseases
  • EBV-associated disease
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Host Species
  • Human


  • Official Symbol
  • LMP-2
  • Introduction
  • Epstein–Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction.
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